Joint meeting of the BEMS and the section Genetic Toxicology of the NVT
Linking Cytotoxicity with Genotoxicity 
NV Organon – Molenstraat 110, Oss, The Netherlands

MEETING RATIONALE

The Belgian Environmental and Mutagen Society (BEMS) and the 'sectie Genetische Toxicologie van de Nederlandse Vereniging voor Toxicologie (NVT)' are organizing a joint meeting hereby celebrating the 25th anniversary of the BEMS. The symposium will focus on the possible impact of cytotoxicity (e.g. necrosis, apoptosis) in genotoxicity testing; and how to quantify relevant endpoints for risk assessment. 

LOCATION

The meeting will take place at the plant of Organon NV in Oss (The Netherlands). We are confident that the program will convince you to attend this meeting where international and national specialists in the field will present their data.

PROGRAM

 
9:00 – 10:00
Registration & coffee
10:00 – 10:15
Welcome & introduction 

Freddy Van Goethem, J&J Pharmaceutical Research & Development, Beerse, Belgium
 

10:15 – 10:50
HTS and HCS methods for measurement of cellular toxicity 
Mirosclav Cik, J&J Pharmaceutical Research & Development, Beerse, Belgium
 

10:50 – 11:25
High throughput screening for in vitro toxicity testing 
Willem Schoonen, NV Organon, Oss, The Netherlands
 

11:25 – 12:00
Data on cytotoxicity and genotoxicity with FA and AT deficient cell lines 
Barbara Godthelp, LUMC, Leiden, The Netherlands
 

12:00 – 12:35
Apoptosis as a guardian of genome integrity 
Enrico Cundari, I.B.P.M. CNR, Rome, Italy
 

12:35 – 14:00
Sandwich lunch
 
14:00 – 14:35
Quantitative translation of in vitro concentrations into in vivo doses
Adriënne Sips, RIVM, Bilthoven, The Netherlands
 

14:35 – 15:10
Follow-up of in vitro positive results: ongoing discussions 
Veronique Thybaud, Aventis Pharma, Vitry sur Seine, France
 

15:10 – 15:45
Photosafety testing: the role of phototoxicity in relation to photogenotoxicity? : 
Cyrille Krul, TNO Quality of Life, Zeist, The Netherlands
 

15:45 – 16:20
Current methods of cancer risk assessment: a critical review 
Wout Slob, RIVM, Bilthoven, The Netherlands
 

16:20 – 16:30
Closing remarks 
Joost van Delft, Past-President section Genetic Toxicology, Maastricht University, The Netherlands
 

16:30 Reception