Joint meeting of the BEMS and the section Genetic Toxicology of the NVT
Linking Cytotoxicity with Genotoxicity 
NV Organon – Molenstraat 110, Oss, The Netherlands


The Belgian Environmental and Mutagen Society (BEMS) and the 'sectie Genetische Toxicologie van de Nederlandse Vereniging voor Toxicologie (NVT)' are organizing a joint meeting hereby celebrating the 25th anniversary of the BEMS. The symposium will focus on the possible impact of cytotoxicity (e.g. necrosis, apoptosis) in genotoxicity testing; and how to quantify relevant endpoints for risk assessment. 


The meeting will take place at the plant of Organon NV in Oss (The Netherlands). We are confident that the program will convince you to attend this meeting where international and national specialists in the field will present their data.


9:00 – 10:00
Registration & coffee
10:00 – 10:15
Welcome & introduction 

Freddy Van Goethem, J&J Pharmaceutical Research & Development, Beerse, Belgium

10:15 – 10:50
HTS and HCS methods for measurement of cellular toxicity 
Mirosclav Cik, J&J Pharmaceutical Research & Development, Beerse, Belgium

10:50 – 11:25
High throughput screening for in vitro toxicity testing 
Willem Schoonen, NV Organon, Oss, The Netherlands

11:25 – 12:00
Data on cytotoxicity and genotoxicity with FA and AT deficient cell lines 
Barbara Godthelp, LUMC, Leiden, The Netherlands

12:00 – 12:35
Apoptosis as a guardian of genome integrity 
Enrico Cundari, I.B.P.M. CNR, Rome, Italy

12:35 – 14:00
Sandwich lunch
14:00 – 14:35
Quantitative translation of in vitro concentrations into in vivo doses
Adriënne Sips, RIVM, Bilthoven, The Netherlands

14:35 – 15:10
Follow-up of in vitro positive results: ongoing discussions 
Veronique Thybaud, Aventis Pharma, Vitry sur Seine, France

15:10 – 15:45
Photosafety testing: the role of phototoxicity in relation to photogenotoxicity? : 
Cyrille Krul, TNO Quality of Life, Zeist, The Netherlands

15:45 – 16:20
Current methods of cancer risk assessment: a critical review 
Wout Slob, RIVM, Bilthoven, The Netherlands

16:20 – 16:30
Closing remarks 
Joost van Delft, Past-President section Genetic Toxicology, Maastricht University, The Netherlands

16:30 Reception